| 421. | Adenosine on the common path of rapid antidepressant action: The coffee paradox | (genomicpress.kglmeridian.com) |
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Yue, Luo, and colleagues discovered that adenosine signalling is the common underlying mechanism of rapid acting antidepressant therapies, unifying the effects of ketamine, ECT and acute intermittent hypoxia. They use genetically encoded sensors, along with extensive mechanistic dissection, to show that all three induce adenosine surges in mood-regulatory circuits via A1 and A2A receptor activation. The mechanism of action of ketamine primarily involves modulation of mitochondrial metabolism as opposed to NMDA receptor antagonism, thereby presenting the possibility for improvements in derivative products with better therapeutic indices. These outcomes offers a rational framework for gauging therapeutic benefit for depression and raise vexing questions about patterns of caffeine consumption in treatment resistant depression, specifically whether the chronic use has a protective effect or whether the acute use impedes treatment response. | |
| 4 points by PaulHoule 4 days ago | 0 comments |
| 422. | Tom Stoppard has died | (bbc.com) |
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The King and Queen pay tribute to a "dear friend who wore his genius lightly". | |
| 9 points by mstep 10 days ago | 0 comments |
| 423. | The missing standard library for multithreading in JavaScript | (github.com) |
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The missing standard library for multithreading in JavaScript (Works in the browser, Node.js, Deno, Bun) - W4G1/multithreading | |
| 9 points by W4G1 4 days ago | 0 comments |
| 424. | Paged Out | (pagedout.institute) |
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| 3 points by varjag 7 days ago | 0 comments |
| 425. | A.I. Videos Have Flooded Social Media. No One Was Ready | (nytimes.com) |
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| 10 points by xnx 1 day ago | 2 comments |
| 426. | Syncthing-Android have had a change of owner/maintainer | (github.com) |
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Description of the issue status Steps to reproduce invite nel0x here and get help to carry on setup build and release: use old maintainers signing allowed? can we play sign? reinstate gh action workflows contact fdroid for release contin... | |
| 13 points by embedding-shape 2 days ago | 2 comments |
| 427. | Albert Michelson's Harmonic Analyzer [pdf] | (engineerguy.com) |
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| 3 points by o4c 4 days ago | 1 comments |
| 428. | Uncloud - Tool for deploying containerised apps across servers without k8s | (uncloud.run) |
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Take your Docker Compose apps to production with zero-downtime deployments, automatic HTTPS, and cross-machine scaling. Self-hosting made reliable without the complexity. | |
| 9 points by rgun 6 days ago | 1 comments |
| 429. | Frank Gehry Died | (bbc.co.uk) |
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Frank Gehry was acclaimed for his love of jagged angles and use of industrial materials. | |
| 3 points by ksajadi 4 days ago | 1 comments |
| 430. | Unreal Tournament 2004 is back | (old.reddit.com) |
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| 5 points by keithoffer 6 days ago | 0 comments |
| 431. | Show HN: I've asked Claude to improve codebase quality 200 times | (gricha.dev) |
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Blog post | |
| 16 points by Gricha 1 day ago | 1 comments |
| 432. | Carrier-grade NAT: The Killer of the "Homelab" | (a6n.co.uk) |
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blog,personal,tech,exchange,active directory, sql, clustering. Active Directory, failover, hashcat, Wi-Fi, hack, Powershell, script, websites | |
| 4 points by type0 4 days ago | 0 comments |
| 433. | Microsoft drops AI sales targets in half after salespeople miss their quotas | (arstechnica.com) |
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Report: Microsoft declared “the era of AI agents” in May, but enterprise customers aren’t buying. | |
| 6 points by OptionOfT 6 days ago | 2 comments |
| 434. | SpaceX to Pursue 2026 IPO Raising Far Above $30B | (bloomberg.com) |
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| 3 points by mfiguiere 18 hours ago | 0 comments |
| 435. | Git's `todo` branch: a versioned todo list in an orphan meta branch | (github.com) |
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Git Source Code Mirror - This is a publish-only repository but pull requests can be turned into patches to the mailing list via GitGitGadget (https://gitgitgadget.github.io/). Please follow Documentation/SubmittingPatches procedure for any of your improvements. - GitHub - git/git at todo | |
| 3 points by betamint 1 day ago | 0 comments |
| 436. | Reverse math shows why hard problems are hard | (quantamagazine.org) |
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Researchers have used metamathematical techniques to show that certain theorems that look superficially distinct are in fact logically equivalent. | |
| 3 points by gsf_emergency_6 8 days ago | 0 comments |
| 437. | BYD's Engine Flexes Between Ethanol, Gasoline, and Electricity | (spectrum.ieee.org) |
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BYD's hybrid engine blends ethanol and electric power, offering Brazilian drivers affordable, flexible fuel options for a sustainable future. | |
| 3 points by thunderbong 4 days ago | 0 comments |
| 438. | How fast can browsers process base64 data? | (lemire.me) |
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| 3 points by mfiguiere 11 days ago | 0 comments |
| 439. | 100000 TPS over a billion rows: the unreasonable effectiveness of SQLite | (andersmurphy.com) |
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A blog mostly about Clojure programming | |
| 22 points by speckx 7 days ago | 0 comments |
| 440. | US could ask foreign tourists for five-year social media history before entry | (bbc.co.uk) |
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The plan would affect people from countries, including the UK, which can fill out a form in lieu of a visa. | |
| 13 points by neversaydie 3 hours ago | 4 comments |
| 441. | Making tiny 0.1cc two stroke engine from scratch | (youtu.be) |
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Merch - https://jellyfishmachine.myspreadshop.com/Let's make ourselves a tiny little model airplane engine! The engine is 0.1cc (.006 ci) displacement and we... | |
| 4 points by pillars 9 days ago | 1 comments |
| 442. | Why doesn't Apple make a standalone Touch ID? | (jeffgeerling.com) |
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| 5 points by thomasjb 6 days ago | 1 comments |
| 443. | Feynman vs. Computer | (entropicthoughts.com) |
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| 4 points by cgdl 5 days ago | 0 comments |
| 444. | Show HN: Web app that lets you send email time capsules | (resurf.me) |
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| 7 points by walrussama 2 days ago | 0 comments |
| 445. | What Will Enter the Public Domain in 2026? | (publicdomainreview.org) |
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At the start of each year, on January 1st, a new crop of works enter the public domain. Find our highlights of what lies in store for 2026 here. | |
| 4 points by herbertl 8 days ago | 0 comments |
| 446. | How Brian Eno Created Ambient 1: Music for Airports (2019) | (reverbmachine.com) |
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In 1978, Brian Eno released Ambient 1: Music for Airports, a landmark album in ambient and electronic music. Although it wasn't the first ambient | |
| 6 points by dijksterhuis 8 days ago | 0 comments |