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241. In 6 violent encounters, evidence contradicts immigration officials' narratives
242. San Francisco Graffiti
243. Video Games as Art
Video games are art, but a strange art: their essence is transformation of the player, not description to the player. This makes meaningful criticism nearly impossible—you can point at the moon, but it’s not the moon, and once someone sees it, they no longer need the pointing.
244. US trade deficit widens by the most in nearly 34 years in November
trade deficit widened by the most in nearly 34 years in November amid a surge in capital goods ​imports, likely driven by an artificial intelligence investment boom, which could prompt economists ‌to trim their economic growth estimates for the fourth quarter.8 billion, the ‌Commerce Department's Bureau of Economic Analysis and Census Bureau said on Thursday.
245. The age of Pump and Dump software
246. US cyber defense chief accidentally uploaded secret government info to ChatGPT
Congress recently grilled the acting chief on mass layoffs and a failed polygraph.
247. India and EU announce landmark trade deal
The long-awaited deal comes as both Delhi and Brussels contend with economic and geopolitical pressure from the US.
248. Scaling PostgreSQL to power 800M ChatGPT users
249. Show HN: I'm building an AI-proof writing tool. How would you defeat it?
Generated by create next app
250. If you're one of the 16,000 Amazon employees getting laid off, read this
251. Doom has been ported to an earbud
252. I was right about ATProto key management
253. RIP Low-Code 2014-2025
Agentic coding presents an existential threat to a broad set of low-code tools.
254. Running the Stupid Cricut Software on Linux
Getting the Cricut Software to run on Linux, under WINE
255. Show HN: An interactive map of US lighthouses and navigational aids
Interactive map of 59,000+ active US Coast Guard lighthouses and navigational aids. View light characteristics, flash patterns, ranges, and locations from the 2025 Light List.
256. Jurassic Park - Tablet device on Nedry's desk? (2012)
What looks like a tablet/ PDA device can be seen on the lefthand side of Nedry's desk. My closest guess is that it is a Motorola Envoy PDA. But, according...
257. Russia using Interpol's wanted list to target critics abroad, leak reveals
A leak exposes for the first time the extent of Russia’s misuse of Interpol to request the arrest of critics.
258. Deutsche Telekom is violating Net Neutrality
If you are a customer of Deutsche Telekom and some websites just won't load, then we might have the solution to your problem!
259. Ask HN: Books to learn 6502 ASM and the Apple II
260. Sweden weighs Franco-British nuclear weapons cooperation
"I say that when we joined NATO, we are fully involved in all discussions, including those in Europe revolving around nuclear weapons," Prime Minister Ulf Kristersson said.
261. The Holy Grail of Linux Binary Compatibility: Musl and Dlopen
The Holy Grail of Linux Binary Compatibility: musl + dlopen
262. Scientists identify brain waves that define the limits of 'you'
At what point do "you" end and the outside world begins? It might feel like a weird question with an obvious answer, but your brain has to work surprisingly hard to judge that boundary.
263. Not all Chess960 positions are equally complex
Abstract page for arXiv paper 2512.14319: Not all Chess960 positions are equally complex
264. OracleGPT: Thought Experiment on an AI Powered Executive
265. Show HN: TUI for managing XDG default applications
TUI for managing XDG default applications. Contribute to mitjafelicijan/xdgctl development by creating an account on GitHub.
266. Had LLM/AI build an unbiased quiz: Where in the World Should I Live?
267. Ask HN: Who do you follow via RSS feed?
268. Laser Eye Surgery
Why I chose to do it, whether I expected it to work, and if it does
269. Maze Algorithms (2017)
270. Glymphatic system clears amyloid beta and tau from brain to plasma in humans
Dysfunction of the glymphatic system has been proposed as a mechanistic link between sleep disruption and Alzheimer’s disease (AD). In animal models, glymphatic impairment alone can drive AD pathology. Whether this system clears amyloid beta (Aβ) and tau in humans remains unknown. In a randomized crossover trial with 39 participants, we found that glymphatic clearance during normal sleep increased morning plasma levels of AD biomarkers compared to sleep deprivation. Participants underwent overnight monitoring using an investigational device that measured dynamic changes in synaptic-metabolic release and glymphatic activity. The observed changes mirrored predictions from a multicompartment model based on published data on Aβ and tau release and clearance. Our findings indicate that sleep-active physiological processes, particularly reduced brain parenchymal resistance, enhance overnight glymphatic clearance of AD biomarkers to plasma. These results support a key role for glymphatic function in AD pathophysiology and suggest its enhancement as a potential therapeutic strategy to slow disease progression. Sleep-active physiological processes enhance overnight glymphatic clearance of Alzheimer’s disease biomarkers into plasma in humans, supporting the critical role of glymphatic function in Alzheimer’s pathophysiology and its potential as a therapeutic target.