| 241. | In 6 violent encounters, evidence contradicts immigration officials' narratives | (reuters.com) |
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| 53 points by petethomas 20 hours ago | 4 comments |
| 242. | San Francisco Graffiti | (walzr.com) |
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| 4 points by walz 3 days ago | 0 comments |
| 243. | Video Games as Art | (gwern.net) |
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Video games are art, but a strange art: their essence is transformation of the player, not description to the player. This makes meaningful criticism nearly impossible—you can point at the moon, but it’s not the moon, and once someone sees it, they no longer need the pointing. | |
| 3 points by andsoitis 3 days ago | 0 comments |
| 244. | US trade deficit widens by the most in nearly 34 years in November | (finance.yahoo.com) |
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trade deficit widened by the most in nearly 34 years in November amid a surge in capital goods imports, likely driven by an artificial intelligence investment boom, which could prompt economists to trim their economic growth estimates for the fourth quarter.8 billion, the Commerce Department's Bureau of Economic Analysis and Census Bureau said on Thursday. | |
| 5 points by thomassmith65 4 hours ago | 4 comments |
| 245. | The age of Pump and Dump software | (tautvilas.medium.com) |
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| 5 points by brisky 2 days ago | 0 comments |
| 246. | US cyber defense chief accidentally uploaded secret government info to ChatGPT | (arstechnica.com) |
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Congress recently grilled the acting chief on mass layoffs and a failed polygraph. | |
| 10 points by goplayoutside 11 hours ago | 0 comments |
| 247. | India and EU announce landmark trade deal | (bbc.com) |
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The long-awaited deal comes as both Delhi and Brussels contend with economic and geopolitical pressure from the US. | |
| 6 points by Palmik 2 days ago | 0 comments |
| 248. | Scaling PostgreSQL to power 800M ChatGPT users | (openai.com) |
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| 5 points by mustaphah 6 days ago | 0 comments |
| 249. | Show HN: I'm building an AI-proof writing tool. How would you defeat it? | (auth-auth.vercel.app) |
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Generated by create next app | |
| 3 points by callmeed 1 day ago | 1 comments |
| 250. | If you're one of the 16,000 Amazon employees getting laid off, read this | (theregister.com) |
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| 4 points by dijksterhuis 5 hours ago | 0 comments |
| 251. | Doom has been ported to an earbud | (doombuds.com) |
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| 6 points by arin-s 4 days ago | 2 comments |
| 252. | I was right about ATProto key management | (notes.nora.codes) |
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| 14 points by todsacerdoti 4 days ago | 1 comments |
| 253. | RIP Low-Code 2014-2025 | (zackliscio.com) |
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Agentic coding presents an existential threat to a broad set of low-code tools. | |
| 12 points by zackliscio 3 days ago | 3 comments |
| 254. | Running the Stupid Cricut Software on Linux | (arthur.pizza) |
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Getting the Cricut Software to run on Linux, under WINE | |
| 5 points by starkparker 3 days ago | 0 comments |
| 255. | Show HN: An interactive map of US lighthouses and navigational aids | (lighthouses.app) |
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Interactive map of 59,000+ active US Coast Guard lighthouses and navigational aids. View light characteristics, flash patterns, ranges, and locations from the 2025 Light List. | |
| 4 points by idd2 4 days ago | 0 comments |
| 256. | Jurassic Park - Tablet device on Nedry's desk? (2012) | (therpf.com) |
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What looks like a tablet/ PDA device can be seen on the lefthand side of Nedry's desk. My closest guess is that it is a Motorola Envoy PDA. But, according... | |
| 4 points by exvi 4 days ago | 0 comments |
| 257. | Russia using Interpol's wanted list to target critics abroad, leak reveals | (bbc.com) |
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A leak exposes for the first time the extent of Russia’s misuse of Interpol to request the arrest of critics. | |
| 5 points by breve 2 days ago | 0 comments |
| 258. | Deutsche Telekom is violating Net Neutrality | (netzbremse.de) |
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If you are a customer of Deutsche Telekom and some websites just won't load, then we might have the solution to your problem! | |
| 11 points by tietjens 4 days ago | 0 comments |
| 259. | Ask HN: Books to learn 6502 ASM and the Apple II | () |
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| 3 points by abkt 2 days ago | 0 comments |
| 260. | Sweden weighs Franco-British nuclear weapons cooperation | (breakingdefense.com) |
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"I say that when we joined NATO, we are fully involved in all discussions, including those in Europe revolving around nuclear weapons," Prime Minister Ulf Kristersson said. | |
| 7 points by saubeidl 1 day ago | 0 comments |
| 261. | The Holy Grail of Linux Binary Compatibility: Musl and Dlopen | (github.com) |
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The Holy Grail of Linux Binary Compatibility: musl + dlopen | |
| 3 points by Splizard 3 days ago | 0 comments |
| 262. | Scientists identify brain waves that define the limits of 'you' | (sciencealert.com) |
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At what point do "you" end and the outside world begins? It might feel like a weird question with an obvious answer, but your brain has to work surprisingly hard to judge that boundary. | |
| 3 points by mikhael 3 days ago | 0 comments |
| 263. | Not all Chess960 positions are equally complex | (arxiv.org) |
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Abstract page for arXiv paper 2512.14319: Not all Chess960 positions are equally complex | |
| 4 points by MaysonL 6 days ago | 0 comments |
| 264. | OracleGPT: Thought Experiment on an AI Powered Executive | (senteguard.com) |
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| 4 points by djwide 3 days ago | 1 comments |
| 265. | Show HN: TUI for managing XDG default applications | (github.com) |
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TUI for managing XDG default applications. Contribute to mitjafelicijan/xdgctl development by creating an account on GitHub. | |
| 5 points by mitjafelicijan 4 days ago | 2 comments |
| 266. | Had LLM/AI build an unbiased quiz: Where in the World Should I Live? | (dev.mkn.us) |
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| 4 points by mknweb 1 day ago | 0 comments |
| 267. | Ask HN: Who do you follow via RSS feed? | () |
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| 3 points by znpy 2 days ago | 0 comments |
| 268. | Laser Eye Surgery | (cremieux.xyz) |
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Why I chose to do it, whether I expected it to work, and if it does | |
| 4 points by MrBuddyCasino 10 hours ago | 0 comments |
| 269. | Maze Algorithms (2017) | (jamisbuck.org) |
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| 7 points by surprisetalk 5 days ago | 2 comments |
| 270. | Glymphatic system clears amyloid beta and tau from brain to plasma in humans | (nature.com) |
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Dysfunction of the glymphatic system has been proposed as a mechanistic link between sleep disruption and Alzheimer’s disease (AD). In animal models, glymphatic impairment alone can drive AD pathology. Whether this system clears amyloid beta (Aβ) and tau in humans remains unknown. In a randomized crossover trial with 39 participants, we found that glymphatic clearance during normal sleep increased morning plasma levels of AD biomarkers compared to sleep deprivation. Participants underwent overnight monitoring using an investigational device that measured dynamic changes in synaptic-metabolic release and glymphatic activity. The observed changes mirrored predictions from a multicompartment model based on published data on Aβ and tau release and clearance. Our findings indicate that sleep-active physiological processes, particularly reduced brain parenchymal resistance, enhance overnight glymphatic clearance of AD biomarkers to plasma. These results support a key role for glymphatic function in AD pathophysiology and suggest its enhancement as a potential therapeutic strategy to slow disease progression. Sleep-active physiological processes enhance overnight glymphatic clearance of Alzheimer’s disease biomarkers into plasma in humans, supporting the critical role of glymphatic function in Alzheimer’s pathophysiology and its potential as a therapeutic target. | |
| 4 points by jmount 15 hours ago | 0 comments |